Adesan

Country: Australia

Language: English

Source: Department of Health (Therapeutic Goods Administration)

Active ingredient:

Candesartan cilexetil

Available from:

Alphapharm Pty Ltd

Class:

Medicine Registered

Patient Information leaflet

ADESAN
®

_contains the active ingredient (candesartan cilexetil)_
CONSUMER MEDICINE INFORMATION

WHAT IS IN THIS LEAFLET
This leaflet answers some common
questions about ADESAN.
It does not contain all the available
information. It does not take the
place of talking to your doctor or
pharmacist.
All medicines have benefits and
risks. Your doctor has weighed the
risks of you taking ADESAN against
the benefits expected for you.
IF YOU HAVE ANY CONCERNS ABOUT
TAKING THIS MEDICINE, TALK TO YOUR
DOCTOR OR PHARMACIST.
KEEP THIS LEAFLET WITH YOUR
MEDICINE.
You may need to read it again.
WHAT ADESAN IS USED
FOR
ADESAN is a type of medicines
called an angiotensin II receptor
inhibitor (or antagonist).
ADESAN is used to treat high blood
pressure, also called hypertension.
ADESAN is also used to treat heart
failure - increase survival, reduce
hospitalization and improve
symptoms. It is used in combination
with other medicines to treat your
condition.
HYPERTENSION:
All people have blood pressure. This
pressure helps to push blood all
around your body. Your blood
pressure changes during the day,
depending on how busy you are or
how you are feeling.
You have hypertension (high blood
pressure) when your blood pressure
stays higher than is needed, even
when you are calm and relaxed.
Regular blood pressure checks are
the only way of knowing that you
have hypertension. There are usually
no symptoms of hypertension and
you may feel fine. If hypertension is
not treated, serious health problems
such as stroke or heart attack and
heart or kidney failure may occur.
ADESAN lowers blood pressure by
dilating (expanding) small blood
vessels from the heart, letting the
blood be pumped around the body
more easily.
HEART FAILURE:
Heart failure means that the heart
muscle cannot pump blood strongly
enough to supply all the blood
needed throughout the body. Heart
failure is not the same as heart attack
and does not mean that the heart
stops working.
Heart failure may start off with no
symptoms, but as the condition
progresses, p

Summary of Product characteristics

ADESAN
®

_Candesartan cilexetil  _
PRODUCT INFORMATION 
NAME OF THE MEDICINE 
Active ingredients: 
Candesartan cilexetil 
Chemical name: 
(±)-1-(cyclohexyloxycarbonyl-oxy)ethyl-2-ethoxy-1-[[2’-(1_H_-tetrazol-5-yl)  biphenyl-
4-yl]methyl]-1_H_-benzimadozole-7-carboxylate 
Structural formula: 

Molecular Formula: 
C
33
H
34
N
6
O
6

Molecular Weight: 
610.66

CAS Registry No.: 145040-37-5 
DESCRIPTION 
Candesartan  cilexetil  a  white  to  off  white  powder  and  is  practically  insoluble  in  water.    Three  polymorphic 
forms have been identified; crystal form I, crystal form II and an amorphous form. Crystalline form I is used in 
ADESAN. 
In  addition  to  candesartan  cilexetil,  ADESAN  tablets  also  contain  lactose,  carmellose  calcium,  glyceryl 
monosterate, hydroxypropylcellulose, iron oxide red
CI77491, maize starch, magnesium stearate. 
PHARMACOLOGY 
PHARMACODYNAMICS

Angiotensin  II  is  the  primary  vasoactive  hormone  of  the  renin-angiotensinaldosterone  system  and  plays  a 
significant  role  in  the  pathophysiology  of  hypertension  and  other  cardiovascular  disorders.    It  also  has  an 
important role in the pathogenesis of end organ hypertrophy and damage.  The major physiological effects of 
angiotensin II, such as vasoconstriction, aldosterone stimulation, regulation of salt and water homeostasis and 
stimulation of cell growth, are mediated via the type 1 (AT
1
) receptor. 
Candesartan cilexetil is a prodrug suitable for oral use.  It is rapidly converted to the active drug, candesartan, 
by ester hydrolysis during absorption from the gastrointestinal tract.  Candesartan is an angiotensin II receptor 
antagonist, selective for AT
1
 receptors, with tight binding to and slow dissociation from the receptor.