情報リーフレット
ADESAN
®
_contains the active ingredient (candesartan cilexetil)_
CONSUMER MEDICINE INFORMATION
WHAT IS IN THIS LEAFLET
This leaflet answers some common
questions about ADESAN.
It does not contain all the available
information. It does not take the
place of talking to your doctor or
pharmacist.
All medicines have benefits and
risks. Your doctor has weighed the
risks of you taking ADESAN against
the benefits expected for you.
IF YOU HAVE ANY CONCERNS ABOUT
TAKING THIS MEDICINE, TALK TO YOUR
DOCTOR OR PHARMACIST.
KEEP THIS LEAFLET WITH YOUR
MEDICINE.
You may need to read it again.
WHAT ADESAN IS USED
FOR
ADESAN is a type of medicines
called an angiotensin II receptor
inhibitor (or antagonist).
ADESAN is used to treat high blood
pressure, also called hypertension.
ADESAN is also used to treat heart
failure - increase survival, reduce
hospitalization and improve
symptoms. It is used in combination
with other medicines to treat your
condition.
HYPERTENSION:
All people have blood pressure. This
pressure helps to push blood all
around your body. Your blood
pressure changes during the day,
depending on how busy you are or
how you are feeling.
You have hypertension (high blood
pressure) when your blood pressure
stays higher than is needed, even
when you are calm and relaxed.
Regular blood pressure checks are
the only way of knowing that you
have hypertension. There are usually
no symptoms of hypertension and
you may feel fine. If hypertension is
not treated, serious health problems
such as stroke or heart attack and
heart or kidney failure may occur.
ADESAN lowers blood pressure by
dilating (expanding) small blood
vessels from the heart, letting the
blood be pumped around the body
more easily.
HEART FAILURE:
Heart failure means that the heart
muscle cannot pump blood strongly
enough to supply all the blood
needed throughout the body. Heart
failure is not the same as heart attack
and does not mean that the heart
stops working.
Heart failure may start off with no
symptoms, but as the condition
progresses, p
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製品の特徴
ADESAN
®
_Candesartan cilexetil _
PRODUCT INFORMATION
NAME OF THE MEDICINE
Active ingredients:
Candesartan cilexetil
Chemical name:
(±)-1-(cyclohexyloxycarbonyl-oxy)ethyl-2-ethoxy-1-[[2’-(1_H_-tetrazol-5-yl) biphenyl-
4-yl]methyl]-1_H_-benzimadozole-7-carboxylate
Structural formula:
Molecular Formula:
C
33
H
34
N
6
O
6
Molecular Weight:
610.66
CAS Registry No.: 145040-37-5
DESCRIPTION
Candesartan cilexetil a white to off white powder and is practically insoluble in water. Three polymorphic
forms have been identified; crystal form I, crystal form II and an amorphous form. Crystalline form I is used in
ADESAN.
In addition to candesartan cilexetil, ADESAN tablets also contain lactose, carmellose calcium, glyceryl
monosterate, hydroxypropylcellulose, iron oxide red
CI77491, maize starch, magnesium stearate.
PHARMACOLOGY
PHARMACODYNAMICS
Angiotensin II is the primary vasoactive hormone of the renin-angiotensinaldosterone system and plays a
significant role in the pathophysiology of hypertension and other cardiovascular disorders. It also has an
important role in the pathogenesis of end organ hypertrophy and damage. The major physiological effects of
angiotensin II, such as vasoconstriction, aldosterone stimulation, regulation of salt and water homeostasis and
stimulation of cell growth, are mediated via the type 1 (AT
1
) receptor.
Candesartan cilexetil is a prodrug suitable for oral use. It is rapidly converted to the active drug, candesartan,
by ester hydrolysis during absorption from the gastrointestinal tract. Candesartan is an angiotensin II receptor
antagonist, selective for AT
1
receptors, with tight binding to and slow dissociation from the receptor.
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