Riik: Austraalia
keel: inglise
Allikas: Department of Health (Therapeutic Goods Administration)
Candesartan cilexetil
Alphapharm Pty Ltd
Medicine Registered
ADESAN ® _contains the active ingredient (candesartan cilexetil)_ CONSUMER MEDICINE INFORMATION WHAT IS IN THIS LEAFLET This leaflet answers some common questions about ADESAN. It does not contain all the available information. It does not take the place of talking to your doctor or pharmacist. All medicines have benefits and risks. Your doctor has weighed the risks of you taking ADESAN against the benefits expected for you. IF YOU HAVE ANY CONCERNS ABOUT TAKING THIS MEDICINE, TALK TO YOUR DOCTOR OR PHARMACIST. KEEP THIS LEAFLET WITH YOUR MEDICINE. You may need to read it again. WHAT ADESAN IS USED FOR ADESAN is a type of medicines called an angiotensin II receptor inhibitor (or antagonist). ADESAN is used to treat high blood pressure, also called hypertension. ADESAN is also used to treat heart failure - increase survival, reduce hospitalization and improve symptoms. It is used in combination with other medicines to treat your condition. HYPERTENSION: All people have blood pressure. This pressure helps to push blood all around your body. Your blood pressure changes during the day, depending on how busy you are or how you are feeling. You have hypertension (high blood pressure) when your blood pressure stays higher than is needed, even when you are calm and relaxed. Regular blood pressure checks are the only way of knowing that you have hypertension. There are usually no symptoms of hypertension and you may feel fine. If hypertension is not treated, serious health problems such as stroke or heart attack and heart or kidney failure may occur. ADESAN lowers blood pressure by dilating (expanding) small blood vessels from the heart, letting the blood be pumped around the body more easily. HEART FAILURE: Heart failure means that the heart muscle cannot pump blood strongly enough to supply all the blood needed throughout the body. Heart failure is not the same as heart attack and does not mean that the heart stops working. Heart failure may start off with no symptoms, but as the condition progresses, p Lugege kogu dokumenti
ADESAN ® _Candesartan cilexetil _ PRODUCT INFORMATION NAME OF THE MEDICINE Active ingredients: Candesartan cilexetil Chemical name: (±)-1-(cyclohexyloxycarbonyl-oxy)ethyl-2-ethoxy-1-[[2’-(1_H_-tetrazol-5-yl) biphenyl- 4-yl]methyl]-1_H_-benzimadozole-7-carboxylate Structural formula: Molecular Formula: C 33 H 34 N 6 O 6 Molecular Weight: 610.66 CAS Registry No.: 145040-37-5 DESCRIPTION Candesartan cilexetil a white to off white powder and is practically insoluble in water. Three polymorphic forms have been identified; crystal form I, crystal form II and an amorphous form. Crystalline form I is used in ADESAN. In addition to candesartan cilexetil, ADESAN tablets also contain lactose, carmellose calcium, glyceryl monosterate, hydroxypropylcellulose, iron oxide red CI77491, maize starch, magnesium stearate. PHARMACOLOGY PHARMACODYNAMICS Angiotensin II is the primary vasoactive hormone of the renin-angiotensinaldosterone system and plays a significant role in the pathophysiology of hypertension and other cardiovascular disorders. It also has an important role in the pathogenesis of end organ hypertrophy and damage. The major physiological effects of angiotensin II, such as vasoconstriction, aldosterone stimulation, regulation of salt and water homeostasis and stimulation of cell growth, are mediated via the type 1 (AT 1 ) receptor. Candesartan cilexetil is a prodrug suitable for oral use. It is rapidly converted to the active drug, candesartan, by ester hydrolysis during absorption from the gastrointestinal tract. Candesartan is an angiotensin II receptor antagonist, selective for AT 1 receptors, with tight binding to and slow dissociation from the receptor. Lugege kogu dokumenti